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Type of Funding
UN SDG
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PTDC/EMD-EMD/30828/2017
PTDC/EMD-EMD/30828/2017
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Financing Type
Call for SR&TD Project Grants - 2017
Amount Financed
€238.605,23
Project Title
Magnetic-responsive perfusable 3D tissue scaffolds for vascularization studies
Main Researcher
Carla Alexandra Moreira Portugal
Institution
NOVA.ID.FCT - Associação para a Inovação e Desenvolvimento da FCT
Scientific Areas
Medical engineering
Sustainable Development Goals
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Abstract
This project aims the development of 3D magnetic-responsive perfusable devices, for production of in vitro biocompatible and non-thrombogenic vascular grafts, which may be used for the replacement of dysfunctional vessels. Furthermore, these magnetic-responsive devices are envisaged to prompt the design of more accurate cell models which faithfully mimic the hierarchical architecture of the native vessel networks. These cell models should allow for a better understanding of the cellular mechanisms underlying vascularization processes, being regarded as a source of knowledge, which may privilege advances of the state of the art in regenerative medicine and the development of novel clinical therapies needed for treatment of vascular and angiogenic related diseases.
Keywords
magnetic-responsive hydrogels
fluid dynamics
cell tissue scaffolds
vascularization
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